MANAGEMENT OF LIVER FAILURE

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Management of liver failure.

In considering a patient in liver failure it is important to distinguish between fulminant hepatic failure (FHF) and episodes of acute hepatic decompensation in patients suffering from chronic liver disease (CLD), as the basis for treatment differs. Fulminant hepatic failure has been defined by Trey and Davidson (1970) as encephalopathy developing within 8 weeks of the onset of symptoms in a pa...

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Management of acute liver failure

An ideal therapy for acute liver failure (ALF) would be the successful promotion of liver regeneration, with spontaneous recovery from the disease. However, in spite of advances in our understanding of the process of regeneration1 and potential candidate compounds for clinical testing,2 we currently lack the ability to influence this process in the patient with ALF. Thus, therapeutic efforts ar...

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Management of Acute Liver Failure

Fulminant hepatic failure, a life threatening condition induced by massive hepatocellular necrosis may be associated with significant morbidity and mortality. A better understanding of the pathophysiology of this condition, associated with advances in intensive care management and liver transplantation have improved outcomes. This review describes recent advances in the management of fulminant ...

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Management of acute liver failure

syndrome that triggers a cascade of events, leading to multiple organ failure and often death. A previously normal liver may fail within days or weeks; and despite recent advances in intensive care and organ support, mortality rates remain high. In those patients with high grades of encephalopathy, the chances of survival are less than 20% with medical management alone. Early deaths in ALF are ...

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Management of acute liver failure.

The principles of management for acute liver failure are: 1. Accurate diagnosis of the type--fulminant, late onset, acute on chronic--and establishment of likely aetiology. 2. Early detection and treatment of complications, particularly metabolic acidosis (early), renal failure, cerebral oedema and infections (late). 3. Optimization of conditions for regeneration by maintenance of normal metabo...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 1986

ISSN: 0007-0912

DOI: 10.1093/bja/58.2.234